ABSTRACT
Coronavirus disease 2019 is predominantly a respiratory illness that can cause hypercoagulable states with multisystem involvement. A single centre retrospective study was carried out in 37 patients who were diagnosed as COVID 19 with AKI from January 2022 to march 2022. Baseline D dimer was evaluated on hospital admission. Patients who were diagnosed with AKI on admission or during the stay in hospital were included in the study, In this study 37 COVID patients with AKI were analysed. Mean age of subjects was 62.51+/-15.18 years. Majority were in the age group 61-70 years (24.3%). 78.4% were males and 21.6% were females. Mean blood urea among subjects was 131.86+/-56.55(mmol/L), mean serum creatinine was 4.71+/-2.52(mg/dl). mean d dimer at admission was 3.701+/-4.48570(mg/L).70.3% of subjects had AKI at hospital admission and 29.7% developed AKI during hospital stay. Cause of AKI was prerenal in 89.2%, renal 18.9%,and post renal in 8.1%. D dimer levels >3.05 had highest validity in predicting the need for RRT with sensitivity 39.29%, specificity 100%, positive predictive value of 100% and negative predictive value of 34.6%. from this study it was concluded that d dimer has specificity of 100%in predicting the need of RRT Copyright © 2023, Research Journal of Pharmaceutical, Biological and Chemical Sciences.All Rights Reserved.
ABSTRACT
Background and Aims: Coronavirus disease 2019 (COVID-19) adds more challenges to the perioperative management of pregnant women. The aim of this study is to examine severity of COVID-19 disease and maternal and foetal outcome among COVID-19 positive pregnant women undergoing caesarean section. Methods: This retrospective observational study was conducted at a tertiary teaching hospital in Karnataka between 1stApril to 31st July 2021, during which 100 COVID-19 positive pregnant women with ASA physical class II, III and IV who have undergone lower segment emergency caesarean section were selected on the basis of simple random sampling method. Results: A total of 100 women who had undergone caesarean section under spinal anaesthesia with positive SARS-CoV-2 PCR tests were assessed. Mean age was 24.45± 4.3 years, eight women were having severe covid-19 infection and overall mortality rate was 5% (5/100) in women and 1 woman had HELPP syndrome and one met with PPH (post-partum haemorrhage). Seven (7%) COVID-19 pregnant women required intensive care in the perioperative period. Eight neonates required NICU admission and had APGAR score less than 7. Fifty-five (55%) women were asymptomatic. While the rate of pneumonia in symptomatic women was 3.6% (8/45), the pneumonia incidence among all SARS-CoV-2 PCR (+) pregnant women was 8% (8/100). Conclusion: In our study, 61% of patients had pulmonary involvement and the mortality rate was 8% among mothers and 1% in neonates.